Plus: the FDA's drug regulator has resigned A West Coast biotech entrepreneur says he's secured $30 million to form a public-benefit company to study how to safely create genetically edited babies, marking the largest known investment into the taboo technology. The new company, called Preventive, is being formed to research so-called "heritable genome editing," in which the DNA of embryos would be modified by correcting harmful mutations or installing beneficial genes. The goal would be to prevent disease. Creating genetically edited humans remains controversial. The first scientist to do it, in China, was imprisoned for three years. The procedure remains illegal in many countries, including the US, and doubts surround its usefulness as a form of medicine.

London-listed miner Anglo American and Canada's Teck Resources plan to merge, marking the sector's second-biggest mergers and acquisitions deal ever and forging a new global copper-focused heavyweight. Under the proposed deal, which will require regulatory approvals and was announced on Tuesday, Anglo American shareholders will own 62.4 percent of the new company, Anglo Teck, while shareholders in Teck would hold 37.6 percent. The deal to form the world's fifth-largest copper company is also a big bet on copper by Anglo. Glencore's $90bn merger with Xstrata in 2013 remains the largest mining deal in history. Copper, used in the power and construction sectors, is set to benefit from burgeoning demand spurred by electric vehicles and artificial intelligence.

Optimal Bayesian decision making on what geoscientific data to acquire requires stating a prior model of uncertainty. Data acquisition is then optimized by reducing uncertainty on some property of interest maximally, and on average. In the context of exploration, very few, sometimes no data at all, is available prior to data acquisition planning. The prior model therefore needs to include human interpretations on the nature of spatial variability, or on analogue data deemed relevant for the area being explored. In mineral exploration, for example, humans may rely on conceptual models on the genesis of the mineralization to define multiple hypotheses, each representing a specific spatial variability of mineralization. More often than not, after the data is acquired, all of the stated hypotheses may be proven incorrect, i.e. falsified, hence prior hypotheses need to be revised, or additional hypotheses generated. Planning data acquisition under wrong geological priors is likely to be inefficient since the estimated uncertainty on the target property is incorrect, hence uncertainty may not be reduced at all. In this paper, we develop an intelligent agent based on partially observable Markov decision processes that plans optimally in the case of multiple geological or geoscientific hypotheses on the nature of spatial variability. Additionally, the artificial intelligence is equipped with a method that allows detecting, early on, whether the human stated hypotheses are incorrect, thereby saving considerable expense in data acquisition. Our approach is tested on a sediment-hosted copper deposit, and the algorithm presented has aided in the characterization of an ultra high-grade deposit in Zambia in 2023.

This paper investigates the forecasting performance of COMEX copper futures realized volatility across various high-frequency intervals using both econometric volatility models and deep learning recurrent neural network models. The econometric models considered are GARCH and HAR, while the deep learning models include RNN (Recurrent Neural Network), LSTM (Long Short-Term Memory), and GRU (Gated Recurrent Unit). In forecasting daily realized volatility for COMEX copper futures with a rolling window approach, the econometric models, particularly HAR, outperform recurrent neural networks overall, with HAR achieving the lowest QLIKE loss function value. However, when the data is replaced with hourly high-frequency realized volatility, the deep learning models outperform the GARCH model, and HAR attains a comparable QLIKE loss function value. Despite the black-box nature of machine learning models, the deep learning models demonstrate superior forecasting performance, surpassing the fixed QLIKE value of HAR in the experiment. Moreover, as the forecast horizon extends for daily realized volatility, deep learning models gradually close the performance gap with the GARCH model in certain loss function metrics. Nonetheless, HAR remains the most effective model overall for daily realized volatility forecasting in copper futures.

Large Language Models (LLMs) have demonstrated remarkable performance in solving math problems, a hallmark of human intelligence. Despite high success rates on current benchmarks; however, these often feature simple problems with only one or two unknowns, which do not sufficiently challenge their reasoning capacities. This paper introduces a novel benchmark, BeyondX, designed to address these limitations by incorporating problems with multiple unknowns. Recognizing the challenges in proposing multi-unknown problems from scratch, we developed BeyondX using an innovative automated pipeline that progressively increases complexity by expanding the number of unknowns in simpler problems. Empirical study on BeyondX reveals that the performance of existing LLMs, even those fine-tuned specifically on math tasks, significantly decreases as the number of unknowns increases - with a performance drop of up to 70\% observed in GPT-4. To tackle these challenges, we propose the Formulate-and-Solve strategy, a generalized prompting approach that effectively handles problems with an arbitrary number of unknowns. Our findings reveal that this strategy not only enhances LLM performance on the BeyondX benchmark but also provides deeper insights into the computational limits of LLMs when faced with more complex mathematical challenges.

In this paper, we explore the optimization of metal recycling with a focus on real-time differentiation between alloys of copper and aluminium. Spectral data, obtained through Prompt Gamma Neutron Activation Analysis (PGNAA), is utilized for classification. The study compares data from two detectors, cerium bromide (CeBr$_{3}$) and high purity germanium (HPGe), considering their energy resolution and sensitivity. We test various data generation, preprocessing, and classification methods, with Maximum Likelihood Classifier (MLC) and Conditional Variational Autoencoder (CVAE) yielding the best results. The study also highlights the impact of different detector types on classification accuracy, with CeBr$_{3}$ excelling in short measurement times and HPGe performing better in longer durations. The findings suggest the importance of selecting the appropriate detector and methodology based on specific application requirements.

The three classes of architectures for time series prediction were tested. They differ by input layers which contain either convolutional, LSTM, or dense hypercomplex layers for 4D algebras. The input was four related Stock Market time series, and the prediction of one of them is expected. The optimization of hyperparameters related to the classes of architectures was performed in order to compare the best neural networks within the class. The results show that in most cases, the architecture with a hypercomplex dense layer provides similar MAE accuracy to other architectures, however, with considerably less trainable parameters. Thanks to it, hypercomplex neural networks can be learned and process data faster than the other tested architectures. Moreover, the order of the input time series has an impact on effectively.

There is a pressing market demand to minimize the test time of Prompt Gamma Neutron Activation Analysis (PGNAA) spectra measurement machine, so that it could function as an instant material analyzer, e.g. to classify waste samples instantaneously and determine the best recycling method based on the detected compositions of the testing sample. This article introduces a new development of the deep learning classification and contrive to reduce the test time for PGNAA machine. We propose both Random Sampling Methods and Class Activation Map (CAM) to generate "downsized" samples and train the CNN model continuously. Random Sampling Methods (RSM) aims to reduce the measuring time within a sample, and Class Activation Map (CAM) is for filtering out the less important energy range of the downsized samples. We shorten the overall PGNAA measuring time down to 2.5 seconds while ensuring the accuracy is around 96.88 % for our dataset with 12 different species of substances. Compared with classifying different species of materials, it requires more test time (sample count rate) for substances having the same elements to archive good accuracy. For example, the classification of copper alloys requires nearly 24 seconds test time to reach 98 % accuracy.

Moog Inc. has automated the evaluation of copper (Cu) alloy grain size using a deep-learning convolutional neural network (CNN). The proof-of-concept automated image acquisition and batch-wise image processing offers the potential for significantly reduced labor, improved accuracy of grain evaluation, and decreased overall turnaround times for approving Cu alloy bar stock for use in flight critical aircraft hardware. A classification accuracy of 91.1% on individual sub-images of the Cu alloy coupons was achieved. Process development included minimizing the variation in acquired image color, brightness, and resolution to create a dataset with 12300 sub-images, and then optimizing the CNN hyperparameters on this dataset using statistical design of experiments (DoE). Over the development of the automated Cu alloy grain size evaluation, a degree of "explainability" in the artificial intelligence (XAI) output was realized, based on the decomposition of the large raw images into many smaller dataset sub-images, through the ability to explain the CNN ensemble image output via inspection of the classification results from the individual smaller sub-images.

Ore deposits are generally formed by hydrothermal activity, which also forms various types of alteration zones in the vicinity of such deposits. Identifying alteration zones can clarify the mineralization mechanism and provides information indispensable for mineral resource exploration. The application of an alteration halo accompanied by the alteration of host rocks to the exploration of the Kuroko ore deposits produced many results in Japan (see, e.g., [1]). It is important to identify the alteration zone in the exploration of porphyry copper deposits. More than 50% of global copper production is from porphyry copper deposits, making them the most important copper resource.